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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are typically focused on the practical aspects of the study design, such as recruitment and consent, adherence, and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and included participants from different geographic areas. This kind of heterogeneity, that is crucial for pragmatic trials to be valid and lessen the chance of bias is also essential. However, too much heterogeneity can cause issues with the design of the trial.
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The aim of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are typically commissioned by policy makers and practitioners to inform their decision making. They can also be used to assess the causal relationship between an intervention and its results. However, 무료 프라그마틱 should not be used to replace explanatory studies.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study which includes the recruitment, design, and delivery of the intervention and follow-up.
There is a growing increase in the number of pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.